Date: Tuesday, 09/15/2009
Location: Hunter College of the City University of New York Department of Biological Sciences Fall 2009 Seminar Series
On September 15th, Kambiz Shekdar will be presenting Chromovert Technology: Rapid Cell Engineering for Systems Biology Applications.
For the first time, it is possible to accurately model complex ion channels and receptors as they exist in vivo with the scalability to effectively navigate systems biology applications. Many ion channels and receptors are expressed in specialized differentiated cells (e.g., neurons, epithelial cells) and have been difficult to reliably model in heterologous cell based assays (e.g., CHO, 293). Chromovert technology uses transient fluorogenic nucleic acid probes to scan millions of individual cells for accelerated isolation of rare, optimal cell lines even for heteromultimeric ion channels and receptors that had eluded prior reduction to cell based assays. Within three months, cell based assays that represent accurate in vitro correlates of in vivo target activity can be produced for any target regardless of its sequence or biology.