North Brunswick, NJ – We will be announcing our work on odorant receptors and modulators at the European Sensory Conference, ECRO, on September 18, 2010.
Discovery platform for odorant potentiators and blockers
We developed methods to test millions of cells to produce panels of cell lines functionally expressing native, full length odorant receptors from multiple species. A subset of prioritized receptors was screened using a library of volatile compounds and resulted in the identification of modulators including novel agonists, potentiators and blockers. Interestingly, potentiators of some receptors performed as blockers of other receptors. This data is being used to guide human sensory evaluation to determine composite effects of identified modulators for blockade of malodors as well as enhancement of desirable fragrances. Data from native taste receptor cell based assays suggest that reliance on native, full length receptors will be critical for accurate decoding of the human olfactory system. This will maximize reliability for effective compound discovery. Data on the Chromovert® technology used to produce functional native odorant receptor cell lines and high throughput screening results will be presented.